UGT1A10

GENE INFORMATION

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Gene name

UGT1A10 (HGNC Symbol)

Synonyms

UGT1J

Description

UDP glucuronosyltransferase 1 family, polypeptide A10 (HGNC Symbol)

Entrez gene summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

233636454 - 233773305

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242515 (version 78.38)

Entrez gene

54575

UniProt

Q9HAW8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HAW8

Antibodypedia

UGT1A10 antibodies
 

PROTEIN VIEW

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UGT1A10-001
 
UGT1A10-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UGT1A10-001 ENSP00000343838
ENST00000344644
Q9HAW8
Show all »
Show » Show » 530 59.8 Yes 1
UGT1A10-002 ENSP00000362544
ENST00000373445
Q9HAW8
Show all »
Show » Show » 441 49.6 Yes 0