PCDHGC4

GENE INFORMATION

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Gene name

PCDHGC4 (HGNC Symbol)

Synonyms

PCDH-GAMMA-C4

Description

Protocadherin gamma subfamily C, 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

141484997 - 141512979

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242419 (version 78.38)

Entrez gene

56098

UniProt

Q9Y5F7 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9Y5F7

Antibodypedia

PCDHGC4 antibodies
 

PROTEIN VIEW

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PCDHGC4-001
 
PCDHGC4-002
 
PCDHGC4-004
 
PCDHGC4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCDHGC4-001 ENSP00000306918
ENST00000306593
Q9Y5F7
Show all »
Show » Show » 938 101.2 No 1
PCDHGC4-002 ENSP00000483845
ENST00000617094
Q9Y5F7
Show all »
Show » Show » 871 94.5 No 1
PCDHGC4-004 ENSP00000478541
ENST00000618371
Q9UKW1
Show all »
Show » 128 13.5 No 0
PCDHGC4-005 ENSP00000478393
ENST00000610539
Show » Show » 83 9.3 No 0