EIF6

GENERAL INFORMATION

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Gene name

EIF6

Gene description

Eukaryotic translation initiation factor 6

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA040873
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

EIF6 (HGNC Symbol)

Synonyms

b(2)gcn, EIF3A, ITGB4BP, p27BBP

Description

Eukaryotic translation initiation factor 6 (HGNC Symbol)

Entrez gene summary

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Chromosome

20

Cytoband

q11.22

Chromosome location (bp)

35278907 - 35284985

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242372 (version 78.38)

Entrez gene

3692

UniProt

P56537 (UniProt - Evidence at protein level)

neXtProt

NX_P56537

Antibodypedia

EIF6 antibodies


PROTEIN BROWSER

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ENST00000374436
 
ENST00000374443
 
ENST00000374450
 
ENST00000456600
 
ENST00000621148
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EIF6-001 ENSP00000363574
ENST00000374450
P56537
Show all »
Show » Show » 245 26.6 No 0
EIF6-002 ENSP00000363559
ENST00000374436
P56537
Show all »
Show » Show » 245 26.6 No 0
EIF6-005 ENSP00000363566
ENST00000374443
P56537
Show all »
Show » Show » 226 23.7 No 0
EIF6-008 ENSP00000390897
ENST00000456600
B7ZBH1
Show all »
Show » Show » 108 11.8 No 0
EIF6-201 ENSP00000483289
ENST00000621148
P56537
Show all »
Show » Show » 245 26.6 No 0