MIF

GENERAL INFORMATION

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Gene name

MIF

Gene description

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly cytoplasmic expression in most types of glandular cells. No or low expression in lymphoid, muscle and neuronal tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA003868 , CAB005284
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MIF (HGNC Symbol)

Synonyms

GIF, GLIF

Description

Macrophage migration inhibitory factor (glycosylation-inhibiting factor) (HGNC Symbol)

Entrez gene summary

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.23

Chromosome location (bp)

23894004 - 23895227

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000240972 (version 78.38)

Entrez gene

4282

UniProt

P14174 (UniProt - Evidence at protein level)

neXtProt

NX_P14174

Antibodypedia

MIF antibodies


PROTEIN BROWSER

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ENST00000215754
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MIF-001 ENSP00000215754
ENST00000215754
P14174
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