NME1

GENE INFORMATION

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Gene name

NME1 (HGNC Symbol)

Synonyms

NDPKA, NM23, NM23-H1

Description

NME/NM23 nucleoside diphosphate kinase 1 (HGNC Symbol)

Entrez gene summary

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.33

Chromosome location (bp)

51153536 - 51162428

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000239672 (version 78.38)

Entrez gene

4830

UniProt

P15531 (UniProt - Evidence at protein level)

neXtProt

NX_P15531

Antibodypedia

NME1 antibodies
 

PROTEIN VIEW

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NME1-001
 
NME1-002
 
NME1-004
 
NME1-005
 
NME1-007
 
NME1-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NME1-001 ENSP00000376892
ENST00000393196
P15531
Show all »
Show » Show » 152 17.1 No 0
NME1-002 ENSP00000337060
ENST00000336097
P15531
Show all »
Show » Show » 177 19.7 Yes 0
NME1-004 ENSP00000013034
ENST00000013034
P15531
Show all »
Show » Show » 177 19.7 Yes 0
NME1-005 ENSP00000387682
ENST00000456492
C9K028
Show all »
Show » Show » 60 6.5 Yes 0
NME1-007 ENSP00000429318
ENST00000480143
E7ERL0
Show all »
Show » Show » 139 15.3 Yes 0
NME1-009 ENSP00000428553
ENST00000511355
E5RHP0
Show all »
Show » Show » 82 9.4 No 0