CKMT1B

GENE INFORMATION

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Gene name

CKMT1B (HGNC Symbol)

Synonyms

CKMT, CKMT1, UMTCK

Description

Creatine kinase, mitochondrial 1B (HGNC Symbol)

Entrez gene summary

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q15.3

Chromosome location (bp)

43593054 - 43604901

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000237289 (version 78.38)

Entrez gene

1159

UniProt

P12532 (UniProt - Evidence at protein level)

neXtProt

NX_P12532

Antibodypedia

CKMT1B antibodies
 

PROTEIN VIEW

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CKMT1B-001
 
CKMT1B-003
 
CKMT1B-004
 
CKMT1B-008
 
CKMT1B-009
 
CKMT1B-012
 
CKMT1B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CKMT1B-001 ENSP00000413255
ENST00000441322
P12532
Show all »
Show » Show » 417 47 Yes 0
CKMT1B-003 ENSP00000413999
ENST00000453782
C9JSQ1
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Show » Show » 241 26.7 Yes 0
CKMT1B-004 ENSP00000391990
ENST00000437924
C9J995
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Show » Show » 129 14.1 Yes 0
CKMT1B-008 ENSP00000416467
ENST00000449946
C9JFS8
Show all »
Show » 96 10.4 Yes 0
CKMT1B-009 ENSP00000396707
ENST00000417289
C9JJX8
Show all »
Show » Show » 103 11.2 Yes 0
CKMT1B-012 ENSP00000411531
ENST00000453733
C9J6W7
Show all »
Show » Show » 203 22.5 Yes 0
CKMT1B-201 ENSP00000300283
ENST00000300283
P12532
Show all »
Show » Show » 417 47 Yes 0