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HLA-B
TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN

Dictionary

GENERAL INFORMATION

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Gene name

 HLA-B

Gene description

 Major histocompatibility complex, class I, B

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

 Evidence at protein level

Protein localization

 Most of the normal tissues displayed moderate to strong cytoplasmic and membranous immunoreactivity. Hepatocytes, cells in the CNS and myocytes were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

 Pending RNA-based expert annotation.

Data reliability

 Uncertain based on 1 antibody.
CAB015418
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis


PROTEIN EXPRESSION OVERVIEW

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Organ

Expression


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression
GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression


GENE INFORMATION

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Gene name

 HLA-B (HGNC Symbol)

Synonyms

 AS

Description

 Major histocompatibility complex, class I, B (HGNC Symbol)

Entrez gene summary

 HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31353872 - 31357188

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000234745 (version 78.38)

Entrez gene

 3106

UniProt

 P01889 (UniProt - Evidence at protein level), P30480 (UniProt - Evidence at protein level), P30486 (UniProt - Evidence at protein level), Q29836 (UniProt - Evidence at protein level), Q31610 (UniProt - Evidence at protein level), Q31612 (UniProt - Evidence at protein level)

neXtProt

 NX_P01889, NX_P30480, NX_P30486, NX_Q29836, NX_Q31610, NX_Q31612

Antibodypedia

 HLA-B antibodies


PROTEIN BROWSER

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ENST00000412585
  
ENST00000434333
  
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HLA-B-001 ENSP00000399168
ENST00000412585 		P01889
Show all » 		Show » Show » 362 40.5 Yes 1
HLA-B-003 ENSP00000405931
ENST00000434333 		F6U0H7
Show all » 		Show » Show » 246 27.8 No 0
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.