GPX1

GENE INFORMATION

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Gene name

GPX1

Synonyms

Description

Glutathione peroxidase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

49357176 - 49358600

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000233276 (version 78.38)

Entrez gene

2876

UniProt

P07203 (UniProt - Evidence at protein level)

neXtProt

NX_P07203

Antibodypedia

GPX1 antibodies
 

PROTEIN VIEW

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GPX1-001
 
GPX1-002
 
GPX1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPX1-001 ENSP00000407375
ENST00000419783
P07203
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Show » Show » 203 22.1 No 0
GPX1-002 ENSP00000391316
ENST00000419349
P07203
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Show » Show » 98 10.3 No 0
GPX1-201 ENSP00000478837
ENST00000620890
A0A024R2T1
Show all »
Show » Show » 202 21.9 No 0