TNF

GENERAL INFORMATION

? »

Gene name

TNF

Gene description

Tumor necrosis factor

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

? »

Data reliability

Pending normal tissue annotation.
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

? »
Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

? »

Gene name

TNF (HGNC Symbol)

Synonyms

DIF, TNF-alpha, TNFA, TNFSF2

Description

Tumor necrosis factor (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31575567 - 31578336

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000232810 (version 78.38)

Entrez gene

7124

UniProt

P01375 (UniProt - Evidence at protein level)

neXtProt

NX_P01375

Antibodypedia

TNF antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000449264
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNF-001 ENSP00000398698
ENST00000449264
P01375
Show all »
Show » Show » 233 25.6 No 0