HSBP1

GENERAL INFORMATION

? »

Gene name

HSBP1

Gene description

Heat shock factor binding protein 1

Protein class

Cytoskeleton related proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate, sometimes granular, cytoplasmic immunoreactivity. Luminal membranes in ciliated cells, respiratory epithelium and fallopian tube, showed strong staining. Strong cytoplasmic and membranous staining was seen in breast and prostate glandular cells. The lung, liver and lymphoid tissues were negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA028940
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

HSBP1

Synonyms

Description

Heat shock factor binding protein 1 (HGNC Symbol)

Entrez gene summary

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q23.3

Chromosome location (bp)

83807843 - 83819737

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000230989 (version 78.38)

Entrez gene

3281

UniProt

O75506 (UniProt - Evidence at protein level)

neXtProt

NX_O75506

Antibodypedia

HSBP1 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000433866
 
ENST00000570259
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSBP1-001 ENSP00000392896
ENST00000433866
O75506
Show all »
Show » Show » 76 8.5 No 0
HSBP1-002 ENSP00000458007
ENST00000570259
O75506
Show all »
Show » Show » 76 8.5 No 0