SLC26A6 - Gene info - The Human Protein Atlas

Gene name

SLC26A6 (HGNC Symbol)

Synonyms

DKFZp586E1422

Description

Solute carrier family 26 (anion exchanger), member 6 (HGNC Symbol)

Entrez gene summary

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

Chromosome

Cytoband

p21.31

Chromosome location (bp)

48625723 - 48635493

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000225697 (version 78.38)

Entrez gene

65010

UniProt

Q9BXS9 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC26A6-001

ENSP00000404684
ENST00000420764

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0012506 [vesicle membrane]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015499 [formate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015659 [formate uptake transmembrane transporter activity]
GO:0015660 [formate efflux transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0015724 [formate transport]
GO:0015797 [mannitol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030165 [PDZ domain binding]
GO:0030321 [transepithelial chloride transport]
GO:0031410 [cytoplasmic vesicle]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034707 [chloride channel complex]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0046724 [oxalic acid secretion]
GO:0048240 [sperm capacitation]
GO:0050892 [intestinal absorption]
GO:0051453 [regulation of intracellular pH]
GO:0051454 [intracellular pH elevation]
GO:0055085 [transmembrane transport]
GO:0070528 [protein kinase C signaling]
GO:0070633 [transepithelial transport]
GO:0071320 [cellular response to cAMP]
GO:0071332 [cellular response to fructose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0097225 [sperm midpiece]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:2001150 [positive regulation of dipeptide transmembrane transport]

758

82.8

SLC26A6-004

ENSP00000378920
ENST00000395550

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

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759

SLC26A6-005

ENSP00000337648
ENST00000337000

G3XAC1
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G3XAC1 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSP00000337648}; Solute carrier family 26, member 6, isoform CRA_i {ECO:0000313|EMBL:EAW64908.1}
Q9Y3Y1 [Target identity:8%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]

651

71.5

SLC26A6-006

ENSP00000373239
ENST00000383733

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

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740

80.8

SLC26A6-009

ENSP00000401066
ENST00000455886

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
C9J6Y3 [Target identity:23%; Query identity:100%]
Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSP00000405872}
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

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723

79.2

SLC26A6-015

ENSP00000389922
ENST00000421649

H7BZJ6
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H7BZJ6 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSP00000389922}

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GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]

303

32.3

SLC26A6-021

ENSP00000401813
ENST00000431739

C9JKR6
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C9JKR6 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSP00000401813}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:1902358 [sulfate transmembrane transport]

180

20.2

SLC26A6-022

ENSP00000405872
ENST00000426599

C9J6Y3
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C9J6Y3 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSP00000405872}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:1902358 [sulfate transmembrane transport]

169

18.8

SLC26A6-201

ENSP00000351597
ENST00000358747

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

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738

80.9

SLC26A6-202

ENSP00000483669
ENST00000614797

Q86YZ4
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Q86YZ4 [Target identity:100%; Query identity:100%]
Solute carrier family 26, member 6 {ECO:0000313|EMBL:BAC56861.1}
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422 {ECO:0000313|EMBL:CAB43306.2}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]

753

82.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.