CKMT1A

GENE INFORMATION

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Gene name

CKMT1A (HGNC Symbol)

Synonyms

CKMT1

Description

Creatine kinase, mitochondrial 1A (HGNC Symbol)

Entrez gene summary

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q15.3

Chromosome location (bp)

43692886 - 43699222

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000223572 (version 78.38)

Entrez gene

548596

UniProt

P12532 (UniProt - Evidence at protein level)

neXtProt

NX_P12532

Antibodypedia

CKMT1A antibodies
 

PROTEIN VIEW

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CKMT1A-001
 
CKMT1A-002
 
CKMT1A-003
 
CKMT1A-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CKMT1A-001 ENSP00000413165
ENST00000434505
P12532
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Show » Show » 417 47 Yes 0
CKMT1A-002 ENSP00000406577
ENST00000413453
P12532
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Show » Show » 417 47 Yes 0
CKMT1A-003 ENSP00000401927
ENST00000415044
C9JT96
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Show » Show » 222 24.6 Yes 0
CKMT1A-004 ENSP00000398973
ENST00000411750
C9J8F6
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Show » Show » 148 16.3 Yes 0