LAT

GENE INFORMATION

? »

Gene name

LAT (HGNC Symbol)

Synonyms

LAT1

Description

Linker for activation of T cells (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

28984826 - 28990783

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213658 (version 78.38)

Entrez gene

27040

UniProt

O43561 (UniProt - Evidence at protein level)

neXtProt

NX_O43561

Antibodypedia

LAT antibodies
 

PROTEIN VIEW

? »
 
 
 
LAT-001
 
LAT-002
 
LAT-004
 
LAT-005
 
LAT-007
 
LAT-011
 
LAT-012
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LAT-001 ENSP00000354119
ENST00000360872
O43561
Show all »
Show » Show » 262 27.9 Yes 0
LAT-002 ENSP00000378845
ENST00000395461
O43561
Show all »
Show » Show » 269 28.6 No 1
LAT-004 ENSP00000378841
ENST00000395456
O43561
Show all »
Show » Show » 233 25 Yes 0
LAT-005 ENSP00000456761
ENST00000566177
O43561
Show all »
Show » Show » 261 27.8 Yes 0
LAT-007 ENSP00000398793
ENST00000454369
O43561
Show all »
Show » Show » 232 24.8 Yes 0
LAT-011 ENSP00000455728
ENST00000570232
H3BQD8
Show all »
Show » Show » 166 17.4 No 0
LAT-012 ENSP00000457036
ENST00000564277
O43561
Show all »
Show » Show » 232 24.8 Yes 0