NRAS

GENE INFORMATION

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Gene name

NRAS (HGNC Symbol)

Synonyms

N-ras

Description

Neuroblastoma RAS viral (v-ras) oncogene homolog (HGNC Symbol)

Entrez gene summary

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

Chromosome

1

Cytoband

p13.2

Chromosome location (bp)

114704469 - 114716894

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213281 (version 78.38)

Entrez gene

4893

UniProt

P01111 (UniProt - Evidence at protein level)

neXtProt

NX_P01111

Antibodypedia

NRAS antibodies
 

PROTEIN VIEW

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NRAS-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NRAS-001 ENSP00000358548
ENST00000369535
P01111
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