DIO1

GENE INFORMATION

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Gene name

DIO1 (HGNC Symbol)

Synonyms

TXDI1

Description

Deiodinase, iodothyronine, type I (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p32.3

Chromosome location (bp)

53891239 - 53911086

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000211452 (version 78.38)

Entrez gene

1733

UniProt

P49895 (UniProt - Evidence at transcript level)

neXtProt

NX_P49895

Antibodypedia

DIO1 antibodies
 

PROTEIN VIEW

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DIO1-001
 
DIO1-002
 
DIO1-009
 
DIO1-010
 
DIO1-013
 
DIO1-014
 
DIO1-017
 
DIO1-201
 
DIO1-202
 
DIO1-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DIO1-001 ENSP00000354643
ENST00000361921
P49895
Show all »
Show » Show » 249 28.9 No 1
DIO1-002 ENSP00000323198
ENST00000322679
P49895
Show all »
Show » Show » 161 18.7 No 1
DIO1-009 ENSP00000373528
ENST00000388876
P49895
Show all »
Show » Show » 201 23.4 No 1
DIO1-010 ENSP00000434758
ENST00000532493
P49895
Show all »
Show » Show » 113 13.2 No 1
DIO1-013 ENSP00000435725
ENST00000525202
P49895
Show all »
Show » Show » 185 21.3 No 1
DIO1-014 ENSP00000434152
ENST00000524406
D3DQ42
Show all »
Show » Show » 120 14 No 0
DIO1-017 ENSP00000432797
ENST00000529589
Show » Show » 184 21.5 No 0
DIO1-201 ENSP00000483367
ENST00000610607
C6ZRB7
Show all »
Show » Show » 84 9.1 No 1
DIO1-202 ENSP00000479755
ENST00000613679
A8K415
Show all »
Show » Show » 248 28.8 No 1
DIO1-203 ENSP00000481665
ENST00000617230
A8K415
Show all »
Show » Show » 160 18.6 No 1