CRLF2

GENE INFORMATION

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Gene name

CRLF2 (HGNC Symbol)

Synonyms

CRL2, TSLPR

Description

Cytokine receptor-like factor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

X

Cytoband

p22.33

Chromosome location (bp)

1187549 - 1212750

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205755 (version 78.38)

Entrez gene

64109

UniProt

Q9HC73 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HC73

Antibodypedia

CRLF2 antibodies
 

PROTEIN VIEW

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CRLF2-001
 
CRLF2-201
 
CRLF2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRLF2-001 ENSP00000383641
ENST00000400841
D0E2W4
Show all »
Show » Show » 371 42 Yes 1
CRLF2-201 ENSP00000370978
ENST00000381566
Q9HC73
Show all »
Show » Show » 371 42 Yes 1
CRLF2-202 ENSP00000370979
ENST00000381567
Show » Show » 259 29.4 No 1