KRT6A

GENE INFORMATION

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Gene name

KRT6A (HGNC Symbol)

Synonyms

CK6C, CK6D, K6C, K6D, KRT6C, KRT6D

Description

Keratin 6A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

52487174 - 52493257

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205420 (version 78.38)

Entrez gene

3853

UniProt

P02538 (UniProt - Evidence at protein level)

neXtProt

NX_P02538

Antibodypedia

KRT6A antibodies
 

PROTEIN VIEW

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KRT6A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT6A-001 ENSP00000369317
ENST00000330722
P02538
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