DCTN1

GENE INFORMATION

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Gene name

DCTN1

Synonyms

Description

Dynactin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

Chromosome

2

Cytoband

p13.1

Chromosome location (bp)

74361154 - 74392087

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204843 (version 78.38)

Entrez gene

1639

UniProt

Q14203 (UniProt - Evidence at protein level)

neXtProt

NX_Q14203

Antibodypedia

DCTN1 antibodies
 

PROTEIN VIEW

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 « 
 
DCTN1-001
 
DCTN1-002
 
DCTN1-004
 
DCTN1-006
 
DCTN1-007
 
DCTN1-011
 
DCTN1-012
 
DCTN1-013
 
DCTN1-014
 
DCTN1-015
 
DCTN1-016
 
DCTN1-017
 
DCTN1-018
 
DCTN1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCTN1-001 ENSP00000354791
ENST00000361874
Q14203
Show all »
Show » Show » 1278 141.7 No 0
DCTN1-002 ENSP00000386843
ENST00000409567
Q14203
Show all »
Show » Show » 1253 138.8 No 0
DCTN1-004 ENSP00000387270
ENST00000409438
Q14203
Show all »
Show » Show » 1139 126.7 No 0
DCTN1-006 ENSP00000386406
ENST00000409240
Q14203
Show all »
Show » Show » 1236 136.8 No 0
DCTN1-007 ENSP00000387327
ENST00000409868
E7EX90
Show all »
Show » Show » 1256 139.1 No 0
DCTN1-011 ENSP00000400059
ENST00000440727
C9J1B7
Show all »
Show » Show » 64 6.8 No 0
DCTN1-012 ENSP00000402509
ENST00000417090
C9JKG6
Show all »
Show » Show » 135 14.4 No 0
DCTN1-013 ENSP00000395312
ENST00000437375
C9JJN7
Show all »
Show » Show » 87 9.3 No 0
DCTN1-014 ENSP00000409363
ENST00000421392
C9JTE5
Show all »
Show » Show » 76 8.1 No 0
DCTN1-015 ENSP00000407484
ENST00000449655
Show » 14 1.4 No 0
DCTN1-016 ENSP00000414315
ENST00000458655
E9PCY0
Show all »
Show » Show » 186 19.5 No 0
DCTN1-017 ENSP00000404038
ENST00000454119
C9JJD0
Show all »
Show » Show » 121 12.9 No 0
DCTN1-018 ENSP00000413268
ENST00000413111
C9JTE5
Show all »
Show » Show » 76 8.1 No 0
DCTN1-201 ENSP00000377571
ENST00000394003
Q14203
Show all »
Show » Show » 1271 140.9 No 0