GABBR1

GENE INFORMATION

? »

Gene name

GABBR1 (HGNC Symbol)

Synonyms

GPRC3A, hGB1a

Description

Gamma-aminobutyric acid (GABA) B receptor, 1 (HGNC Symbol)

Entrez gene summary

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]

Chromosome

6

Cytoband

p22.1

Chromosome location (bp)

29555629 - 29633976

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204681 (version 78.38)

Entrez gene

2550

UniProt

Q9UBS5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBS5

Antibodypedia

GABBR1 antibodies
 

PROTEIN VIEW

? »
 
 
 
GABBR1-001
 
GABBR1-002
 
GABBR1-003
 
GABBR1-004
 
GABBR1-015
 
GABBR1-016
 
GABBR1-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GABBR1-001 ENSP00000366233
ENST00000377034
Q9UBS5
Show all »
Show » Show » 961 108.3 Yes 7
GABBR1-002 ENSP00000348248
ENST00000355973
Q9UBS5
Show all »
Show » Show » 844 95.1 Yes 7
GABBR1-003 ENSP00000366215
ENST00000377016
Q9UBS5
Show all »
Show » Show » 899 101.5 Yes 7
GABBR1-004 ENSP00000366211
ENST00000377012
Q9UBS5
Show all »
Show » Show » 844 95.1 Yes 7
GABBR1-015 ENSP00000419755
ENST00000462632
C9JZG6
Show all »
Show » 156 17.2 Yes 0
GABBR1-016 ENSP00000417332
ENST00000476670
C9J342
Show all »
Show » 133 14.6 Yes 0
GABBR1-201 ENSP00000366176
ENST00000376977
Q9UBS5
Show all »
Show » Show » 578 65.1 Yes 0