HLA-G

GENERAL INFORMATION

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Gene name

HLA-G

Gene description

Major histocompatibility complex, class I, G

Protein class

Cancer-related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in extravillous trophoblasts.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB016158
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

HLA-G

Synonyms

Description

Major histocompatibility complex, class I, G (HGNC Symbol)

Entrez gene summary

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p22.1

Chromosome location (bp)

29826967 - 29831125

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204632 (version 78.38)

Entrez gene

3135

UniProt

P17693 (UniProt - Evidence at protein level)

neXtProt

NX_P17693

Antibodypedia

HLA-G antibodies


PROTEIN BROWSER

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ENST00000360323
 
ENST00000376815
 
ENST00000376818
 
ENST00000376828
 
ENST00000428701
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-G-001 ENSP00000353472
ENST00000360323
P17693
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Show » Show » 338 38.2 Yes 1
HLA-G-002 ENSP00000366024
ENST00000376828
Q5RJ85
Show all »
Show » Show » 343 38.8 Yes 1
HLA-G-004 ENSP00000366014
ENST00000376818
Q31611
Show all »
Show » Show » 246 27.7 Yes 1
HLA-G-006 ENSP00000366011
ENST00000376815
Q29897
Show all »
Show » Show » 154 17.1 Yes 1
HLA-G-201 ENSP00000412927
ENST00000428701
P17693
Show all »
Show » Show » 338 38.2 Yes 1