DDR1

GENERAL INFORMATION

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Gene name

DDR1

Gene description

Discoidin domain receptor tyrosine kinase 1

Protein class

CD markers
Enzymes
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

43
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A majority of cells display moderate cytoplasmic and membrane expression, most abundant in female, male and gastrointestinal tract tissue.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA057194 , CAB010162 , CAB025656
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DDR1 (HGNC Symbol)

Synonyms

CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6

Description

Discoidin domain receptor tyrosine kinase 1 (HGNC Symbol)

Entrez gene summary

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

30876421 - 30900156

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204580 (version 78.38)

Entrez gene

780

UniProt

Q08345 (UniProt - Evidence at protein level)

neXtProt

NX_Q08345

Antibodypedia

DDR1 antibodies


PROTEIN BROWSER

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ENST00000324771
 
ENST00000376567
 
ENST00000376568
 
ENST00000376569
 
ENST00000376570
 
ENST00000376575
 
ENST00000396342
 
ENST00000412274
 
ENST00000417521
 
ENST00000418800
 
ENST00000421124
 
ENST00000424544
 
ENST00000428153
 
ENST00000437124
 
ENST00000446312
 
ENST00000452441
 
ENST00000454612
 
ENST00000460944
 
ENST00000484556
 
ENST00000502955
 
ENST00000503180
 
ENST00000503495
 
ENST00000503670
 
ENST00000504651
 
ENST00000504679
 
ENST00000504927
 
ENST00000505066
 
ENST00000505534
 
ENST00000507046
 
ENST00000507901
 
ENST00000508312
 
ENST00000508317
 
ENST00000509639
 
ENST00000511510
 
ENST00000512336
 
ENST00000512694
 
ENST00000512725
 
ENST00000513043
 
ENST00000513240
 
ENST00000514434
 
ENST00000515219
 
ENST00000515233
 
ENST00000515881
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDR1-001 ENSP00000406091
ENST00000454612
Q08345
Show all »
Show » Show » 876 97.2 Yes 2
DDR1-002 ENSP00000365752
ENST00000376568
Q08345
Show all »
Show » Show » 913 101.1 Yes 2
DDR1-003 ENSP00000365753
ENST00000376569
Q08345
Show all »
Show » Show » 876 97.2 Yes 2
DDR1-005 ENSP00000318217
ENST00000324771
Q08345
Show all »
Show » Show » 913 101.1 Yes 2
DDR1-006 ENSP00000365751
ENST00000376567
Q08345
Show all »
Show » Show » 876 97.2 Yes 2
DDR1-007 ENSP00000398682
ENST00000417521
A2ABM8
Show all »
Show » Show » 493 53.8 No 1
DDR1-009 ENSP00000424003
ENST00000484556
Show » Show » 277 30.8 No 0
DDR1-010 ENSP00000426420
ENST00000460944
E7EPH4
Show all »
Show » Show » 286 31.9 Yes 0
DDR1-012 ENSP00000407699
ENST00000418800
Q08345
Show all »
Show » Show » 876 97.2 Yes 2
DDR1-013 ENSP00000379631
ENST00000396342
A2ABL0
Show all »
Show » 147 16.2 Yes 0
DDR1-014 ENSP00000390593
ENST00000428153
E7EQ30
Show all »
Show » Show » 267 29.6 Yes 0
DDR1-015 ENSP00000422974
ENST00000503670
D6R9C4
Show all »
Show » 41 4.4 Yes 0
DDR1-016 ENSP00000409682
ENST00000421124
A2ABL2
Show all »
Show » Show » 209 23.2 Yes 0
DDR1-018 ENSP00000427552
ENST00000513240
Q08345
Show all »
Show » Show » 919 101.8 Yes 1
DDR1-020 ENSP00000422442
ENST00000508312
Q08345
Show all »
Show » Show » 894 99.1 Yes 2
DDR1-022 ENSP00000421189
ENST00000505066
E7EVW6
Show all »
Show » 132 14.5 Yes 0
DDR1-023 ENSP00000424346
ENST00000502955
D6RB82
Show all »
Show » 55 5.8 Yes 0
DDR1-024 ENSP00000420833
ENST00000505534
E7EN94
Show all »
Show » 101 10.8 Yes 0
DDR1-025 ENSP00000424468
ENST00000503180
D6RB35
Show all »
Show » 51 5.4 Yes 0
DDR1-026 ENSP00000423906
ENST00000504679
E7ETX3
Show all »
Show » 122 13.2 Yes 0
DDR1-027 ENSP00000423749
ENST00000503495
E7EUP7
Show all »
Show » Show » 196 21.5 Yes 0
DDR1-028 ENSP00000427369
ENST00000508317
E7EUD5
Show all »
Show » 127 13.8 Yes 0
DDR1-030 ENSP00000422331
ENST00000509639
E7ES06
Show all »
Show » 115 12.2 Yes 0
DDR1-031 ENSP00000392413
ENST00000412274
D6RBU7
Show all »
Show » 58 6.1 Yes 0
DDR1-032 ENSP00000424703
ENST00000507901
E7EXB0
Show all »
Show » 78 8.1 Yes 0
DDR1-034 ENSP00000425713
ENST00000507046
E7EQ23
Show all »
Show » 70 7.4 Yes 0
DDR1-035 ENSP00000425113
ENST00000511510
E7ESR9
Show all »
Show » 143 15.8 Yes 0
DDR1-036 ENSP00000394273
ENST00000437124
E7ERI6
Show all »
Show » 153 16.9 Yes 0
DDR1-037 ENSP00000424758
ENST00000504651
E7EX99
Show all »
Show » 73 7.7 Yes 0
DDR1-038 ENSP00000423928
ENST00000513043
D6RB35
Show all »
Show » 51 5.4 Yes 0
DDR1-039 ENSP00000426229
ENST00000512694
E7EPN2
Show all »
Show » 170 18.8 Yes 0
DDR1-040 ENSP00000422467
ENST00000515233
E7ERN0
Show all »
Show » 138 15.3 Yes 0
DDR1-041 ENSP00000423492
ENST00000515881
E7ENJ2
Show all »
Show » 85 9 Yes 0
DDR1-044 ENSP00000421152
ENST00000515219
D6RGW5
Show all »
Show » Show » 69 7.8 No 0
DDR1-047 ENSP00000427597
ENST00000504927
E7ETI3
Show all »
Show » 160 17.6 Yes 0
DDR1-048 ENSP00000421719
ENST00000512336
E7EVT1
Show all »
Show » 112 11.9 Yes 0
DDR1-049 ENSP00000422108
ENST00000512725
E7ERN0
Show all »
Show » 138 15.3 Yes 0
DDR1-050 ENSP00000409400
ENST00000424544
Show » 196 21.8 Yes 0
DDR1-051 ENSP00000427124
ENST00000514434
Show » Show » 172 18.5 No 0
DDR1-205 ENSP00000365754
ENST00000376570
Q08345
Show all »
Show » Show » 876 97.2 Yes 2
DDR1-206 ENSP00000365759
ENST00000376575
Q08345
Show all »
Show » Show » 243 27.1 Yes 0
DDR1-207 ENSP00000405998
ENST00000446312
E7EPH4
Show all »
Show » Show » 767 85.5 Yes 1
DDR1-208 ENSP00000405039
ENST00000452441
Q08345
Show all »
Show » Show » 913 101.1 Yes 2