HSPA1A

GENERAL INFORMATION

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Gene name

HSPA1A

Gene description

Heat shock 70kDa protein 1A

Protein class

Cancer-related genes
Mitochondrial proteins
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 3 antibodies.
HPA052504 , CAB017451 , CAB032815
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HSPA1A (HGNC Symbol)

Synonyms

HSP70-1, HSPA1

Description

Heat shock 70kDa protein 1A (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31815464 - 31817946

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204389 (version 78.38)

Entrez gene

3303

UniProt

P08107 (UniProt - Evidence at protein level)

neXtProt

NX_P08107

Antibodypedia

HSPA1A antibodies


PROTEIN BROWSER

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ENST00000375651
 
ENST00000608703
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPA1A-001 ENSP00000364802
ENST00000375651
P08107
Show all »
Show » Show » 641 70.1 No 0
HSPA1A-002 ENSP00000477378
ENST00000608703
V9GZ37
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Show » Show » 476 51.9 No 0