HSPA1B

GENERAL INFORMATION

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Gene name

HSPA1B

Gene description

Heat shock 70kDa protein 1B

Protein class

Cancer-related genes
Mitochondrial proteins
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression of varying intensity in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Data reliability

Uncertain based on 2 antibodies.
HPA052504 , CAB008640
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HSPA1B (HGNC Symbol)

Synonyms

HSP70-2

Description

Heat shock 70kDa protein 1B (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31827735 - 31830255

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204388 (version 78.38)

Entrez gene

3304

UniProt

P08107 (UniProt - Evidence at protein level)

neXtProt

NX_P08107

Antibodypedia

HSPA1B antibodies


PROTEIN BROWSER

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ENST00000375650
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPA1B-001 ENSP00000364801
ENST00000375650
P08107
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