HSD17B8

GENE INFORMATION

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Gene name

HSD17B8 (HGNC Symbol)

Synonyms

D6S2245E, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1

Description

Hydroxysteroid (17-beta) dehydrogenase 8 (HGNC Symbol)

Entrez gene summary

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

33204642 - 33206831

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204228 (version 78.38)

Entrez gene

7923

UniProt

Q92506 (UniProt - Evidence at protein level)

neXtProt

NX_Q92506

Antibodypedia

HSD17B8 antibodies
 

PROTEIN VIEW

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HSD17B8-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSD17B8-001 ENSP00000363794
ENST00000374662
Q92506
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