CD247

GENE INFORMATION

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Gene name

CD247 (HGNC Symbol)

Synonyms

CD3H, CD3Q, CD3Z

Description

CD247 molecule (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q24.2

Chromosome location (bp)

167430640 - 167518610

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198821 (version 78.38)

Entrez gene

919

UniProt

P20963 (UniProt - Evidence at protein level)

neXtProt

NX_P20963

Antibodypedia

CD247 antibodies
 

PROTEIN VIEW

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CD247-001
 
CD247-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD247-001 ENSP00000375969
ENST00000392122
P20963
Show all »
Show » Show » 163 18.6 Yes 1
CD247-002 ENSP00000354782
ENST00000362089
P20963
Show all »
Show » Show » 164 18.7 Yes 1