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The gene information section lists the gene name (HUGO Gene Nomenclature Committee (HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
Gene name
PLN (HGNC Symbol)
Synonyms
CMD1P, PLB
Description
Phospholamban (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
(read more), and at the bottom of the protein view is the protein scale.
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
GO:0002026 [regulation of the force of heart contraction] GO:0004857 [enzyme inhibitor activity] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008015 [blood circulation] GO:0008016 [regulation of heart contraction] GO:0010043 [response to zinc ion] GO:0010459 [negative regulation of heart rate] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020 [membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031982 [vesicle] GO:0032780 [negative regulation of ATPase activity] GO:0032868 [response to insulin] GO:0033574 [response to testosterone] GO:0042030 [ATPase inhibitor activity] GO:0042802 [identical protein binding] GO:0043086 [negative regulation of catalytic activity] GO:0043234 [protein complex] GO:0045822 [negative regulation of heart contraction] GO:0048471 [perinuclear region of cytoplasm] GO:0048738 [cardiac muscle tissue development] GO:0051117 [ATPase binding] GO:0051260 [protein homooligomerization] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051924 [regulation of calcium ion transport] GO:0051926 [negative regulation of calcium ion transport] GO:0055119 [relaxation of cardiac muscle] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0086023 [adrenergic receptor signaling pathway involved in heart process] GO:0086036 [regulation of cardiac muscle cell membrane potential] GO:0086092 [regulation of the force of heart contraction by cardiac conduction] GO:0090279 [regulation of calcium ion import] GO:0090281 [negative regulation of calcium ion import] GO:0090534 [calcium ion-transporting ATPase complex] GO:1901020 [negative regulation of calcium ion transmembrane transporter activity] GO:1901077 [regulation of relaxation of muscle] GO:1901877 [negative regulation of calcium ion binding] GO:1901894 [regulation of calcium-transporting ATPase activity] GO:1901895 [negative regulation of calcium-transporting ATPase activity] GO:1901897 [regulation of relaxation of cardiac muscle] GO:1902081 [negative regulation of calcium ion import into sarcoplasmic reticulum]
