ADAMTSL2

GENE INFORMATION

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Gene name

ADAMTSL2 (HGNC Symbol)

Synonyms

KIAA0605

Description

ADAMTS-like 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia. [provided by RefSeq, Feb 2009]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

133532164 - 133575519

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197859 (version 78.38)

Entrez gene

9719

UniProt

Q86TH1 (UniProt - Evidence at protein level)

neXtProt

NX_Q86TH1

Antibodypedia

ADAMTSL2 antibodies
 

PROTEIN VIEW

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ADAMTSL2-001
 
ADAMTSL2-002
 
ADAMTSL2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTSL2-001 ENSP00000346478
ENST00000354484
Q86TH1
Show all »
Show » Show » 951 104.6 Yes 0
ADAMTSL2-002 ENSP00000376781
ENST00000393061
B1B0D4
Show all »
Show » Show » 1060 116.3 No 0
ADAMTSL2-201 ENSP00000376780
ENST00000393060
Q86TH1
Show all »
Show » Show » 951 104.6 Yes 0