OCLN

GENE INFORMATION

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Gene name

OCLN (HGNC Symbol)

Synonyms

PPP1R115

Description

Occludin (HGNC Symbol)

Entrez gene summary

This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]

Chromosome

5

Cytoband

q13.2

Chromosome location (bp)

69492292 - 69558104

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197822 (version 78.38)

Entrez gene

100506658

UniProt

Q16625 (UniProt - Evidence at protein level)

neXtProt

NX_Q16625

Antibodypedia

OCLN antibodies
 

PROTEIN VIEW

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OCLN-001
 
OCLN-002
 
OCLN-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OCLN-001 ENSP00000347379
ENST00000355237
Q16625
Show all »
Show » Show » 522 59.1 No 4
OCLN-002 ENSP00000379719
ENST00000396442
Q16625
Show all »
Show » Show » 522 59.1 No 4
OCLN-201 ENSP00000445940
ENST00000538151
Q16625
Show all »
Show » Show » 271 31.6 Yes 0