CYP2B6

GENERAL INFORMATION

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Gene name

CYP2B6

Gene description

Cytochrome P450, family 2, subfamily B, polypeptide 6

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression most abundant in hepatocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 2 antibodies.
HPA048124 , CAB033866
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

CYP2B6 (HGNC Symbol)

Synonyms

CPB6, CYP2B, CYPIIB6

Description

Cytochrome P450, family 2, subfamily B, polypeptide 6 (HGNC Symbol)

Entrez gene summary

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

40991299 - 41018398

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197408 (version 78.38)

Entrez gene

1555

UniProt

P20813 (UniProt - Evidence at protein level)

neXtProt

NX_P20813

Antibodypedia

CYP2B6 antibodies


PROTEIN BROWSER

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ENST00000324071
 
ENST00000593831
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2B6-001 ENSP00000324648
ENST00000324071
P20813
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Show » Show » 491 56.3 Yes 0
CYP2B6-002 ENSP00000470582
ENST00000593831
M0QZJ2
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Show » Show » 255 29.1 No 0