IL27

GENE INFORMATION

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Gene name

IL27 (HGNC Symbol)

Synonyms

IL-27, IL-27A, IL27A, IL27p28, IL30, MGC71873, p28

Description

Interleukin 27 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

Chromosome location (bp)

28499362 - 28512051

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197272 (version 78.38)

Entrez gene

246778

UniProt

Q8NEV9 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NEV9

Antibodypedia

IL27 antibodies
 

PROTEIN VIEW

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IL27-001
 
IL27-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL27-001 ENSP00000349365
ENST00000356897
Q8NEV9
Show all »
Show » Show » 243 27.5 Yes 0
IL27-002 ENSP00000455990
ENST00000568075
H3BQY2
Show all »
Show » 24 3.1 No 0