TPSB2

GENE INFORMATION

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Gene name

TPSB2

Synonyms

Description

Tryptase beta 2 (gene/pseudogene) (HGNC Symbol)

Entrez gene summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

1227272 - 1230184

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197253 (version 78.38)

Entrez gene

64499

UniProt

P20231 (UniProt - Evidence at protein level)

neXtProt

NX_P20231

Antibodypedia

TPSB2 antibodies
 

PROTEIN VIEW

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TPSB2-001
 
TPSB2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPSB2-001 ENSP00000482743
ENST00000606293
P20231
Show all »
Show » Show » 275 30.7 Yes 0
TPSB2-201 ENSP00000478695
ENST00000612142
Show » Show » 282 31.4 Yes 0