SRGAP2B

GENE INFORMATION

? »

Gene name

SRGAP2B (HGNC Symbol)

Synonyms

SRGAP2P2

Description

SLIT-ROBO Rho GTPase activating protein 2B (HGNC Symbol)

Entrez gene summary

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]

Chromosome

1

Cytoband

q21.1

Chromosome location (bp)

144887265 - 145095528

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000196369 (version 78.38)

Entrez gene

647135

UniProt

P0DMP2 (UniProt - Inferred from homology)

neXtProt

NX_P0DMP2

Antibodypedia

SRGAP2B antibodies
 

PROTEIN VIEW

? »
 
 
 
SRGAP2B-001
 
SRGAP2B-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SRGAP2B-001 ENSP00000477776
ENST00000612199
P0DMP2
Show all »
Show » Show » 458 53.4 No 0
SRGAP2B-201 ENSP00000479960
ENST00000619678
Show » 305 35.3 No 0