GRM7 - Gene info - The Human Protein Atlas

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GRM7

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	GRM7 (HGNC Symbol)
Synonyms	GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87
Description	Glutamate receptor, metabotropic 7 (HGNC Symbol)
Entrez gene summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Chromosome	3
Cytoband	p26.1
Chromosome location (bp)	6770001 - 7741533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196277 (version 78.38)
Entrez gene	2917
UniProt	Q14831 (UniProt - Evidence at protein level)
neXtProt	NX_Q14831
Antibodypedia	GRM7 antibodies

PROTEIN VIEW

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GRM7-001		GRM7-003		GRM7-009		GRM7-012		GRM7-015		GRM7-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM7-001	ENSP00000350348 ENST00000357716	Q14831 Show all » « Hide Q14831 [Direct mapping] Metabotropic glutamate receptor 7 C9JU97 [Target identity:13%; Query identity:100%] Metabotropic glutamate receptor 7 {ECO:0000313\|Ensembl:ENSP00000393799}	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001642 [group III metabotropic glutamate receptor activity] GO:0001661 [conditioned taste aversion] GO:0001662 [behavioral fear response] GO:0004930 [G-protein coupled receptor activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005938 [cell cortex] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0007613 [memory] GO:0007614 [short-term memory] GO:0008066 [glutamate receptor activity] GO:0008306 [associative learning] GO:0010855 [adenylate cyclase inhibitor activity] GO:0014050 [negative regulation of glutamate secretion] GO:0016021 [integral component of membrane] GO:0016595 [glutamate binding] GO:0019226 [transmission of nerve impulse] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030534 [adult behavior] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031279 [regulation of cyclase activity] GO:0032279 [asymmetric synapse] GO:0033555 [multicellular organismal response to stress] GO:0042734 [presynaptic membrane] GO:0043198 [dendritic shaft] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0048786 [presynaptic active zone] GO:0050877 [neurological system process] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070588 [calcium ion transmembrane transport] GO:0070905 [serine binding]	915	102.3	Yes	7
GRM7-003	ENSP00000373987 ENST00000389336	Q14831 Show all » « Hide Q14831 [Direct mapping] Metabotropic glutamate receptor 7 C9JU97 [Target identity:13%; Query identity:100%] Metabotropic glutamate receptor 7 {ECO:0000313\|Ensembl:ENSP00000393799}	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005938 [cell cortex] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0008066 [glutamate receptor activity] GO:0010855 [adenylate cyclase inhibitor activity] GO:0014050 [negative regulation of glutamate secretion] GO:0016021 [integral component of membrane] GO:0016595 [glutamate binding] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031279 [regulation of cyclase activity] GO:0032279 [asymmetric synapse] GO:0042734 [presynaptic membrane] GO:0043198 [dendritic shaft] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0048786 [presynaptic active zone] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070905 [serine binding]	906	101.3	Yes	7
GRM7-009	ENSP00000395035 ENST00000445087	C9JMT3 Show all » « Hide C9JMT3 [Target identity:100%; Query identity:100%] Metabotropic glutamate receptor 7 {ECO:0000313\|Ensembl:ENSP00000395035}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane]	185	21.2	No	0
GRM7-012	ENSP00000393799 ENST00000448328	C9JU97 Show all » « Hide C9JU97 [Target identity:100%; Query identity:100%] Metabotropic glutamate receptor 7 {ECO:0000313\|Ensembl:ENSP00000393799}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane]	122	13.5	No	0
GRM7-015	ENSP00000417536 ENST00000486284	Q14831 Show all » « Hide Q14831 [Direct mapping] Metabotropic glutamate receptor 7 C9JU97 [Target identity:13%; Query identity:100%] Metabotropic glutamate receptor 7 {ECO:0000313\|Ensembl:ENSP00000393799}	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005938 [cell cortex] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0008066 [glutamate receptor activity] GO:0010855 [adenylate cyclase inhibitor activity] GO:0014050 [negative regulation of glutamate secretion] GO:0016021 [integral component of membrane] GO:0016595 [glutamate binding] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031279 [regulation of cyclase activity] GO:0032279 [asymmetric synapse] GO:0042734 [presynaptic membrane] GO:0043198 [dendritic shaft] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0048786 [presynaptic active zone] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070905 [serine binding]	922	103.1	Yes	7
GRM7-201	ENSP00000384585 ENST00000402647	C9JU97 Show all » « Hide C9JU97 [Target identity:17%; Query identity:100%] Metabotropic glutamate receptor 7 {ECO:0000313\|Ensembl:ENSP00000393799}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane]	714	80.4	No	7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.