COL25A1

GENE INFORMATION

? »

Gene name

COL25A1

Synonyms

Description

Collagen, type XXV, alpha 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

108810721 - 109302657

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188517 (version 78.38)

Entrez gene

84570

UniProt

Q9BXS0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BXS0

Antibodypedia

COL25A1 antibodies
 

PROTEIN VIEW

? »
 
 
 
COL25A1-001
 
COL25A1-002
 
COL25A1-003
 
COL25A1-005
 
COL25A1-007
 
COL25A1-201
 
COL25A1-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COL25A1-001 ENSP00000382083
ENST00000399132
Q9BXS0
Show all »
Show » Show » 654 64.8 No 0
COL25A1-002 ENSP00000382077
ENST00000399126
Q9BXS0
Show all »
Show » Show » 642 63.7 No 1
COL25A1-003 ENSP00000382078
ENST00000399127
A8MWQ5
Show all »
Show » Show » 645 63.4 No 1
COL25A1-005 ENSP00000422266
ENST00000505591
D6R8Y2
Show all »
Show » 70 7.3 No 0
COL25A1-007 ENSP00000426841
ENST00000512961
Show » 29 2.9 No 0
COL25A1-201 ENSP00000482699
ENST00000610288
Show » 333 34 No 0
COL25A1-202 ENSP00000484110
ENST00000622134
Show » 494 47.8 No 0