PDCD1

GENE INFORMATION

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Gene name

PDCD1 (HGNC Symbol)

Synonyms

CD279, hSLE1, PD1, SLEB2

Description

Programmed cell death 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.3

Chromosome location (bp)

241849881 - 241858908

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188389 (version 78.38)

Entrez gene

5133

UniProt

Q15116 (UniProt - Evidence at protein level)

neXtProt

NX_Q15116

Antibodypedia

PDCD1 antibodies
 

PROTEIN VIEW

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PDCD1-001
 
PDCD1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDCD1-001 ENSP00000335062
ENST00000334409
Q15116
Show all »
Show » Show » 288 31.6 No 1
PDCD1-003 ENSP00000340808
ENST00000343705
Q86TL7
Show all »
Show » 123 13.8 No 0