DAZ3

GENE INFORMATION

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Gene name

DAZ3

Synonyms

Description

Deleted in azoospermia 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]

Chromosome

Y

Cytoband

q11.23

Chromosome location (bp)

24763069 - 24813492

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187191 (version 78.38)

Entrez gene

57135

UniProt

Q9NR90 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR90

Antibodypedia

DAZ3 antibodies
 

PROTEIN VIEW

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DAZ3-001
 
DAZ3-201
 
DAZ3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAZ3-001 ENSP00000371802
ENST00000382365
Q9NR90
Show all »
Show » Show » 438 49.5 No 0
DAZ3-201 ENSP00000324965
ENST00000315357
E7ETR3
Show all »
Show » Show » 366 41.3 No 0
DAZ3-202 ENSP00000401049
ENST00000446723
E7ERQ6
Show all »
Show » Show » 390 44.1 No 0