CYP4F3

GENE INFORMATION

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Gene name

CYP4F3 (HGNC Symbol)

Synonyms

CYP4F, LTB4H

Description

Cytochrome P450, family 4, subfamily F, polypeptide 3 (HGNC Symbol)

Entrez gene summary

This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

19

Cytoband

p13.12

Chromosome location (bp)

15615617 - 15662825

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186529 (version 78.38)

Entrez gene

4051

UniProt

Q08477 (UniProt - Evidence at protein level)

neXtProt

NX_Q08477

Antibodypedia

CYP4F3 antibodies
 

PROTEIN VIEW

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CYP4F3-001
 
CYP4F3-002
 
CYP4F3-004
 
CYP4F3-005
 
CYP4F3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP4F3-001 ENSP00000221307
ENST00000221307
Q08477
Show all »
Show » Show » 520 59.8 No 0
CYP4F3-002 ENSP00000466988
ENST00000591058
Q08477
Show all »
Show » Show » 520 59.7 No 0
CYP4F3-004 ENSP00000466395
ENST00000586182
Q08477
Show all »
Show » Show » 520 59.7 No 0
CYP4F3-005 ENSP00000468105
ENST00000585846
Q08477
Show all »
Show » Show » 520 59.7 No 0
CYP4F3-201 ENSP00000478605
ENST00000620621
Show » Show » 523 60 Yes 1