FCAR

GENE INFORMATION

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Gene name

FCAR (HGNC Symbol)

Synonyms

CD89

Description

Fc fragment of IgA, receptor for (HGNC Symbol)

Entrez gene summary

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54874248 - 54890472

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186431 (version 78.38)

Entrez gene

2204

UniProt

P24071 (UniProt - Evidence at protein level)

neXtProt

NX_P24071

Antibodypedia

FCAR antibodies
 

PROTEIN VIEW

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FCAR-001
 
FCAR-002
 
FCAR-003
 
FCAR-004
 
FCAR-005
 
FCAR-006
 
FCAR-007
 
FCAR-008
 
FCAR-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FCAR-001 ENSP00000347714
ENST00000355524
P24071
Show all »
Show » Show » 287 32.3 Yes 1
FCAR-002 ENSP00000375605
ENST00000391725
P24071
Show all »
Show » Show » 265 29.7 Yes 1
FCAR-003 ENSP00000338257
ENST00000345937
P24071
Show all »
Show » Show » 191 21.7 Yes 1
FCAR-004 ENSP00000338058
ENST00000353758
P24071
Show all »
Show » Show » 178 19.6 No 1
FCAR-005 ENSP00000352218
ENST00000359272
P24071
Show all »
Show » Show » 275 30.9 No 1
FCAR-006 ENSP00000473814
ENST00000469767
P24071
Show all »
Show » Show » 239 27 Yes 0
FCAR-007 ENSP00000375603
ENST00000391723
P24071
Show all »
Show » Show » 209 23.4 No 0
FCAR-008 ENSP00000375604
ENST00000391724
P24071
Show all »
Show » Show » 253 28.3 No 1
FCAR-009 ENSP00000375606
ENST00000391726
P24071
Show all »
Show » Show » 179 20.4 No 1