BCAP31 - Gene info - The Human Protein Atlas

Gene name

BCAP31 (HGNC Symbol)

Synonyms

6C6-Ag, BAP31, CDM, DXS1357E

Description

B-cell receptor-associated protein 31 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]

Chromosome

Cytoband

q28

Chromosome location (bp)

153700497 - 153724697

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185825 (version 78.38)

Entrez gene

10134

UniProt

P51572 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCAP31-001

ENSP00000343458
ENST00000345046

P51572
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P51572 [Direct mapping]
B-cell receptor-associated protein 31
C9J0M4 [Target identity:76%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000400345}
C9JQ75 [Target identity:76%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000409888}
C9JSP1 [Target identity:73%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000394270}
C9JMD7 [Target identity:72%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000389740}
C9JM14 [Target identity:56%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

246

BCAP31-002

ENSP00000392330
ENST00000458587

P51572
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P51572 [Direct mapping]
B-cell receptor-associated protein 31
C9J0M4 [Target identity:60%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000400345}
C9JQ75 [Target identity:59%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000409888}
C9JSP1 [Target identity:58%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000394270}
C9JMD7 [Target identity:56%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000389740}
C9JM14 [Target identity:44%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

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GO:0000139 [Golgi membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0032403 [protein complex binding]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0032580 [Golgi cisterna membrane]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0042288 [MHC class I protein binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0051561 [positive regulation of mitochondrial calcium ion concentration]
GO:0070973 [protein localization to endoplasmic reticulum exit site]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

313

34.8

BCAP31-004

ENSP00000394270
ENST00000416815

C9JSP1
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C9JSP1 [Target identity:100%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000394270}
C9JMD7 [Target identity:97%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000389740}
C9JM14 [Target identity:75%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]

182

20.7

BCAP31-005

ENSP00000409888
ENST00000429550

C9JQ75
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C9JQ75 [Target identity:100%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000409888}
C9JSP1 [Target identity:97%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000394270}
C9JMD7 [Target identity:95%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000389740}
C9JM14 [Target identity:73%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

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GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]

187

21.2

BCAP31-006

ENSP00000400345
ENST00000442093

C9J0M4
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C9J0M4 [Target identity:100%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000400345}
C9JQ75 [Target identity:99%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000409888}
C9JSP1 [Target identity:96%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000394270}
C9JMD7 [Target identity:94%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000389740}
C9JM14 [Target identity:73%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

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GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]

188

21.3

BCAP31-007

ENSP00000402342
ENST00000430088

C9JM14
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C9JM14 [Target identity:100%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

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GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]

138

BCAP31-009

ENSP00000389740
ENST00000423827

C9JMD7
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C9JMD7 [Target identity:100%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000389740}
C9JM14 [Target identity:77%; Query identity:100%]
B-cell receptor-associated protein 31 {ECO:0000313|Ensembl:ENSP00000402342}

Show » « Hide

GO:0005783 [endoplasmic reticulum]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]

178

20.2

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.