PBX1 - Gene info - The Human Protein Atlas

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PBX1

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PBX1
Synonyms
Description	Pre-B-cell leukemia homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	164555584 - 164899296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185630 (version 78.38)
Entrez gene	5087
UniProt	P40424 (UniProt - Evidence at protein level)
neXtProt	NX_P40424
Antibodypedia	PBX1 antibodies

PROTEIN VIEW

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PBX1-001		PBX1-002		PBX1-006		PBX1-007		PBX1-009		PBX1-012		PBX1-013		PBX1-017		PBX1-018		PBX1-019		PBX1-201		PBX1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PBX1-001	ENSP00000405890 ENST00000420696	P40424 Show all » « Hide P40424 [Direct mapping] Pre-B-cell leukemia transcription factor 1 A0A024R919 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1, isoform CRA_b {ECO:0000313\|EMBL:EAW90740.1} H0YLB0 [Target identity:75%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452727}; Pre-B-cell leukemia transcription factor 1, isoform CRA_a {ECO:0000313\|EMBL:EAW90738.1} F8WA05 [Target identity:39%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000341455} H0YKH1 [Target identity:36%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452804} H0YLT4 [Target identity:32%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:29%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:22%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262} Q68DD6 [Target identity:22%; Query identity:100%] Putative uncharacterized protein DKFZp686B09108 {ECO:0000313\|EMBL:CAH18284.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001655 [urogenital system development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006694 [steroid biosynthetic process] GO:0007548 [sex differentiation] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0009887 [organ morphogenesis] GO:0009952 [anterior/posterior pattern specification] GO:0009954 [proximal/distal pattern formation] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0030278 [regulation of ossification] GO:0030325 [adrenal gland development] GO:0030326 [embryonic limb morphogenesis] GO:0035162 [embryonic hemopoiesis] GO:0042127 [regulation of cell proliferation] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0048568 [embryonic organ development] GO:0048706 [embryonic skeletal system development]	430	46.6	No	0
PBX1-002	ENSP00000356872 ENST00000367897	P40424 Show all » « Hide P40424 [Direct mapping] Pre-B-cell leukemia transcription factor 1 Q53YC7 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|EMBL:AAP35351.1}; Pre-B-cell leukemia transcription factor 1, isoform CRA_c {ECO:0000313\|EMBL:EAW90741.1} F8WA05 [Target identity:48%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000341455} H0YKH1 [Target identity:45%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452804} H0YLT4 [Target identity:39%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:36%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:27%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006694 [steroid biosynthetic process] GO:0007548 [sex differentiation] GO:0008134 [transcription factor binding] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]	347	38.4	No	0
PBX1-006	ENSP00000473998 ENST00000485769	S4R377 Show all » « Hide S4R377 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000473998}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]	70	7.4	No	0
PBX1-007	ENSP00000341455 ENST00000340699	F8WA05 Show all » « Hide F8WA05 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000341455}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	170	18.2	No	0
PBX1-009	ENSP00000453163 ENST00000482110	H0YLD4 Show all » « Hide H0YLD4 [Target identity:99%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:75%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	129	14.3	No	0
PBX1-012	ENSP00000453188 ENST00000559240	H0YLF5 Show all » « Hide H0YLF5 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453188} F8WA05 [Target identity:50%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000341455} H0YKH1 [Target identity:46%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452804} H0YLT4 [Target identity:40%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:37%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:28%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]	339	37	No	0
PBX1-013	ENSP00000452804 ENST00000559578	H0YKH1 Show all » « Hide H0YKH1 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452804} H0YLM3 [Target identity:61%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	159	17.6	No	0
PBX1-017	ENSP00000452727 ENST00000560641	H0YLB0 Show all » « Hide H0YLB0 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452727}; Pre-B-cell leukemia transcription factor 1, isoform CRA_a {ECO:0000313\|EMBL:EAW90738.1} H0YLT4 [Target identity:42%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:39%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} Q68DD6 [Target identity:30%; Query identity:100%] Putative uncharacterized protein DKFZp686B09108 {ECO:0000313\|EMBL:CAH18284.1} H0YLM3 [Target identity:29%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	325	35.2	No	0
PBX1-018	ENSP00000453262 ENST00000559560	H0YLM3 Show all » « Hide H0YLM3 [Target identity:100%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	97	10.5	No	0
PBX1-019	ENSP00000453331 ENST00000558837	H0YLT4 Show all » « Hide H0YLT4 [Target identity:99%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:92%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:69%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	139	15.6	No	0
PBX1-201	ENSP00000439943 ENST00000540236	H0YLB0 Show all » « Hide H0YLB0 [Target identity:95%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000452727}; Pre-B-cell leukemia transcription factor 1, isoform CRA_a {ECO:0000313\|EMBL:EAW90738.1} H0YLT4 [Target identity:40%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:37%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:28%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262} Q68DD6 [Target identity:28%; Query identity:100%] Putative uncharacterized protein DKFZp686B09108 {ECO:0000313\|EMBL:CAH18284.1}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	342	37.1	No	0
PBX1-202	ENSP00000483563 ENST00000612123	H0YLT4 Show all » « Hide H0YLT4 [Target identity:53%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453331} H0YLD4 [Target identity:49%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453163} H0YLM3 [Target identity:37%; Query identity:100%] Pre-B-cell leukemia transcription factor 1 {ECO:0000313\|Ensembl:ENSP00000453262}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus]	259	28.9	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.