PARK2

GENE INFORMATION

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Gene name

PARK2 (HGNC Symbol)

Synonyms

AR-JP, parkin, PDJ

Description

Parkin RBR E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q26

Chromosome location (bp)

161347420 - 162727771

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185345 (version 78.38)

Entrez gene

5071

UniProt

O60260 (UniProt - Evidence at protein level)

neXtProt

NX_O60260

Antibodypedia

PARK2 antibodies
 

PROTEIN VIEW

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PARK2-001
 
PARK2-002
 
PARK2-003
 
PARK2-004
 
PARK2-005
 
PARK2-006
 
PARK2-201
 
PARK2-202
 
PARK2-203
 
PARK2-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARK2-001 ENSP00000355860
ENST00000366894
O60260
Show all »
Show » Show » 274 30.6 No 0
PARK2-002 ENSP00000355858
ENST00000366892
B1AKC3
Show all »
Show » Show » 368 40.5 No 0
PARK2-003 ENSP00000343589
ENST00000338468
O60260
Show all »
Show » Show » 274 30.6 No 0
PARK2-004 ENSP00000355865
ENST00000366898
O60260
Show all »
Show » Show » 465 51.6 No 0
PARK2-005 ENSP00000355863
ENST00000366897
O60260
Show all »
Show » Show » 437 48.7 No 0
PARK2-006 ENSP00000355862
ENST00000366896
O60260
Show all »
Show » Show » 316 35.6 No 0
PARK2-201 ENSP00000483773
ENST00000610470
M4T2U2
Show all »
Show » Show » 176 19.7 No 0
PARK2-202 ENSP00000480716
ENST00000612485
Show » 74 8 No 0
PARK2-203 ENSP00000478353
ENST00000612540
Q5XNR7
Show all »
Show » 201 21.8 No 0
PARK2-204 ENSP00000484112
ENST00000615065
Q5XNR7
Show all »
Show » 87 9.2 No 0