IL3RA

GENE INFORMATION

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Gene name

IL3RA (HGNC Symbol)

Synonyms

CD123

Description

Interleukin 3 receptor, alpha (low affinity) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Chromosome

X

Cytoband

p22.33

Chromosome location (bp)

1336616 - 1382689

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185291 (version 78.38)

Entrez gene

3563

UniProt

P26951 (UniProt - Evidence at protein level)

neXtProt

NX_P26951

Antibodypedia

IL3RA antibodies
 

PROTEIN VIEW

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IL3RA-001
 
IL3RA-002
 
IL3RA-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL3RA-001 ENSP00000327890
ENST00000331035
P26951
Show all »
Show » Show » 378 43.3 Yes 1
IL3RA-002 ENSP00000414867
ENST00000432757
J3JS34
Show all »
Show » Show » 164 18.7 Yes 0
IL3RA-201 ENSP00000370878
ENST00000381469
P26951
Show all »
Show » Show » 300 34.5 Yes 1