MC2R

GENE INFORMATION

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Gene name

MC2R (HGNC Symbol)

Synonyms

ACTHR

Description

Melanocortin 2 receptor (adrenocorticotropic hormone) (HGNC Symbol)

Entrez gene summary

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

18

Cytoband

p11.21

Chromosome location (bp)

13882044 - 13915707

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185231 (version 78.38)

Entrez gene

4158

UniProt

Q01718 (UniProt - Evidence at protein level)

neXtProt

NX_Q01718

Antibodypedia

MC2R antibodies
 

PROTEIN VIEW

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MC2R-001
 
MC2R-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MC2R-001 ENSP00000333821
ENST00000327606
Q01718
Show all »
Show » Show » 297 33.9 No 7
MC2R-002 ENSP00000382718
ENST00000399821
R4GMM0
Show all »
Show » Show » 123 13.8 No 3