NELFA

GENE INFORMATION

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Gene name

NELFA (HGNC Symbol)

Synonyms

NELF-A, WHSC2

Description

Negative elongation factor complex member A (HGNC Symbol)

Entrez gene summary

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

1982714 - 2041903

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185049 (version 78.38)

Entrez gene

7469

UniProt

Q9H3P2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H3P2

Antibodypedia

NELFA antibodies
 

PROTEIN VIEW

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NELFA-001
 
NELFA-003
 
NELFA-006
 
NELFA-010
 
NELFA-011
 
NELFA-012
 
NELFA-015
 
NELFA-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NELFA-001 ENSP00000372335
ENST00000382882
Q9H3P2
Show all »
Show » Show » 539 58.5 No 0
NELFA-003 ENSP00000387647
ENST00000416258
H0Y3X6
Show all »
Show » Show » 532 58 No 0
NELFA-006 ENSP00000395761
ENST00000431323
C9JHL4
Show all »
Show » Show » 294 32.4 No 0
NELFA-010 ENSP00000396996
ENST00000411649
Show » 187 20.6 No 0
NELFA-011 ENSP00000410154
ENST00000455762
C9JEM7
Show all »
Show » Show » 208 22.9 No 0
NELFA-012 ENSP00000405119
ENST00000453740
Show » 246 26.4 No 0
NELFA-015 ENSP00000399165
ENST00000411638
Q9H3P2
Show all »
Show » Show » 528 57.3 No 0
NELFA-201 ENSP00000445757
ENST00000542778
Q9H3P2
Show all »
Show » Show » 539 58.5 No 0