LCN12

GENERAL INFORMATION

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Gene name

LCN12

Gene description

Lipocalin 12

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube, thyroid gland)
GTEx:Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein localization

Moderate cytoplasmic positivity was observed in most normal tissues. Nasopharynx, pancreas, thyroid gland and placental trophoblasts were strongly stained. Strong nuclear staining was observed in seminiferus duct cells. Most CNS and lymphoid tissues were weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA024680
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube, thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

LCN12 (HGNC Symbol)

Synonyms

MGC48935

Description

Lipocalin 12 (HGNC Symbol)

Entrez gene summary

Members of the lipocalin family, such as LCN12, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

136949551 - 136955497

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184925 (version 78.38)

Entrez gene

286256

UniProt

Q6JVE5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6JVE5

Antibodypedia

LCN12 antibodies


PROTEIN BROWSER

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ENST00000371632
 
ENST00000371633
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LCN12-003 ENSP00000360695
ENST00000371632
Q5SQ16
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Show » 90 9.8 No 0
LCN12-015 ENSP00000360696
ENST00000371633
Q6JVE5
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Show » Show » 192 21.5 Yes 0