Tissue expression of PLA2G6 - Summary - The Human Protein Atlas

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PLA2G6

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PLA2G6
Gene description	Phospholipase A2, group VI (cytosolic, calcium-independent)
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins RAS pathway related proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed moderate to strong cytoplasmic positivity. Hepatocytes, cells in CNS and myocytes were generally negative.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. HPA001171
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PLA2G6 (HGNC Symbol)
Synonyms	iPLA2, iPLA2beta, NBIA2, PARK14, PNPLA9
Description	Phospholipase A2, group VI (cytosolic, calcium-independent) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	38111495 - 38205690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184381 (version 78.38)
Entrez gene	8398
UniProt	O60733 (UniProt - Evidence at protein level)
neXtProt	NX_O60733
Antibodypedia	PLA2G6 antibodies

PROTEIN BROWSER

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ENST00000332509		ENST00000335539		ENST00000402064		ENST00000417303		ENST00000427114		ENST00000427453		ENST00000430886		ENST00000435484		ENST00000436218		ENST00000447598		ENST00000452542		ENST00000452794		ENST00000455341		ENST00000498338		ENST00000594306

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G6-001	ENSP00000333142 ENST00000332509	O60733 Show all » « Hide O60733 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 M0R1Q9 [Target identity:14%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000472058} F8WEQ9 [Target identity:9%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000393761} M0R3D9 [Target identity:6%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001934 [positive regulation of protein phosphorylation] GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007613 [memory] GO:0008152 [metabolic process] GO:0008219 [cell death] GO:0014832 [urinary bladder smooth muscle contraction] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0032049 [cardiolipin biosynthetic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043008 [ATP-dependent protein binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045909 [positive regulation of vasodilation] GO:0045921 [positive regulation of exocytosis] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047499 [calcium-independent phospholipase A2 activity] GO:0051967 [negative regulation of synaptic transmission, glutamatergic] GO:0060135 [maternal process involved in female pregnancy] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090238 [positive regulation of arachidonic acid secretion] GO:1901339 [regulation of store-operated calcium channel activity] GO:2000304 [positive regulation of ceramide biosynthetic process]	806	89.9	No	1
PLA2G6-002	ENSP00000386100 ENST00000402064	O60733 Show all » « Hide O60733 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 M0R1Q9 [Target identity:15%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000472058} F8WEQ9 [Target identity:10%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000393761} M0R3D9 [Target identity:6%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0008152 [metabolic process] GO:0008219 [cell death] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0032049 [cardiolipin biosynthetic process] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046474 [glycerophospholipid biosynthetic process]	752	84.1	No	1
PLA2G6-003	ENSP00000413597 ENST00000435484	F2Z3G2 Show all » « Hide F2Z3G2 [Target identity:100%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000413597} M0R3D9 [Target identity:50%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		99	11.1	No	0
PLA2G6-005	ENSP00000404974 ENST00000417303	F2Z3G2 Show all » « Hide F2Z3G2 [Target identity:100%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000413597} M0R3D9 [Target identity:50%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		99	11.1	No	0
PLA2G6-007	ENSP00000393761 ENST00000455341	F8WEQ9 Show all » « Hide F8WEQ9 [Target identity:98%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000393761} M0R3D9 [Target identity:62%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		80	9.2	No	0
PLA2G6-010	ENSP00000393361 ENST00000447598	F2Z3G2 Show all » « Hide F2Z3G2 [Target identity:100%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000413597} M0R3D9 [Target identity:50%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		99	11.1	No	0
PLA2G6-012	ENSP00000401242 ENST00000436218	F8WEN3 Show all » « Hide F8WEN3 [Target identity:100%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000401242} F8WEQ9 [Target identity:52%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000393761} M0R3D9 [Target identity:33%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		151	17.4	No	0
PLA2G6-014	ENSP00000395464 ENST00000430886	B0QYE9 Show all » « Hide B0QYE9 [Target identity:100%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000395464} M0R3D9 [Target identity:30%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	166	18.6	No	0
PLA2G6-015	ENSP00000472058 ENST00000498338	M0R1Q9 Show all » « Hide M0R1Q9 [Target identity:100%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000472058}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	120	13.2	No	0
PLA2G6-016	ENSP00000407743 ENST00000427114		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	229	25	No	0
PLA2G6-017	ENSP00000412629 ENST00000452542		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	197	21.4	No	0
PLA2G6-018	ENSP00000408298 ENST00000427453		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	157	17.2	No	0
PLA2G6-019	ENSP00000392968 ENST00000452794		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	124	13.1	No	0
PLA2G6-027	ENSP00000473160 ENST00000594306	M0R3D9 Show all » « Hide M0R3D9 [Target identity:98%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		51	5.8	No	0
PLA2G6-201	ENSP00000335149 ENST00000335539	O60733 Show all » « Hide O60733 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 M0R1Q9 [Target identity:15%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000472058} F8WEQ9 [Target identity:10%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000393761} M0R3D9 [Target identity:6%; Query identity:100%] 85/88 kDa calcium-independent phospholipase A2 {ECO:0000313\|Ensembl:ENSP00000473160}	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0008152 [metabolic process] GO:0008219 [cell death] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0032049 [cardiolipin biosynthetic process] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046474 [glycerophospholipid biosynthetic process]	752	84.1	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx