EFNA5

GENE INFORMATION

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Gene name

EFNA5 (HGNC Symbol)

Synonyms

AF1, EPLG7, LERK7

Description

Ephrin-A5 (HGNC Symbol)

Entrez gene summary

Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q21.3

Chromosome location (bp)

107376889 - 107670895

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184349 (version 78.38)

Entrez gene

1946

UniProt

P52803 (UniProt - Evidence at protein level)

neXtProt

NX_P52803

Antibodypedia

EFNA5 antibodies
 

PROTEIN VIEW

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EFNA5-001
 
EFNA5-003
 
EFNA5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EFNA5-001 ENSP00000328777
ENST00000333274
P52803
Show all »
Show » Show » 228 26.3 Yes 1
EFNA5-003 ENSP00000426989
ENST00000509503
D6RDV5
Show all »
Show » Show » 201 23.3 Yes 1
EFNA5-201 ENSP00000484681
ENST00000611503
Show » Show » 188 21.7 No 1