IRAK1 - Gene info - The Human Protein Atlas

Gene name

IRAK1 (HGNC Symbol)

Synonyms

IRAK, pelle

Description

Interleukin-1 receptor-associated kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q28

Chromosome location (bp)

154010500 - 154019980

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184216 (version 78.38)

Entrez gene

3654

UniProt

P51617 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRAK1-001

ENSP00000358991
ENST00000369974

P51617
Show all » « Hide

P51617 [Direct mapping]
Interleukin-1 receptor-associated kinase 1

Show » « Hide

Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000187 [activation of MAPK activity]
GO:0001959 [regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007254 [JNK cascade]
GO:0010008 [endosome membrane]
GO:0016301 [kinase activity]
GO:0016567 [protein ubiquitination]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032496 [response to lipopolysaccharide]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045323 [interleukin-1 receptor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]

633

IRAK1-002

ENSP00000377291
ENST00000393687

P51617
Show all » « Hide

P51617 [Direct mapping]
Interleukin-1 receptor-associated kinase 1

Show » « Hide

682

73.4

IRAK1-003

ENSP00000406249
ENST00000437278

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

276

28.9

IRAK1-005

ENSP00000403730
ENST00000443220

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

392

42.1

IRAK1-010

ENSP00000410953
ENST00000444254

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0016772 [transferase activity, transferring phosphorus-containing groups]

218

22.6

IRAK1-012

ENSP00000358997
ENST00000369980

P51617
Show all » « Hide

P51617 [Direct mapping]
Interleukin-1 receptor-associated kinase 1

Show » « Hide

GO:0000187 [activation of MAPK activity]
GO:0001959 [regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007254 [JNK cascade]
GO:0007568 [aging]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016567 [protein ubiquitination]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031072 [heat shock protein binding]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045323 [interleukin-1 receptor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071456 [cellular response to hypoxia]

712

76.5

IRAK1-016

ENSP00000411809
ENST00000455690

H7C3G8
Show all » « Hide

H7C3G8 [Target identity:100%; Query identity:100%]
Interleukin-1 receptor-associated kinase 1 {ECO:0000313|Ensembl:ENSP00000411809}
L8E7M9 [Target identity:40%; Query identity:100%]
Alternative protein IRAK1 {ECO:0000313|EMBL:CCQ43144.1}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

212

23.5

IRAK1-017

ENSP00000399974
ENST00000444230

H7C1F0
Show all » « Hide

H7C1F0 [Target identity:100%; Query identity:100%]
Interleukin-1 receptor-associated kinase 1 {ECO:0000313|Ensembl:ENSP00000399974}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]

234

25.3

IRAK1-020

ENSP00000392662
ENST00000429936

D3YTB5
Show all » « Hide

D3YTB5 [Target identity:100%; Query identity:100%]
Interleukin-1 receptor-associated kinase 1 {ECO:0000313|Ensembl:ENSP00000392662}

Show » « Hide

SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

708

76.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.