TMPRSS2

GENE INFORMATION

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Gene name

TMPRSS2 (HGNC Symbol)

Synonyms

PRSS10

Description

Transmembrane protease, serine 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

41464551 - 41531116

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184012 (version 78.38)

Entrez gene

7113

UniProt

O15393 (UniProt - Evidence at protein level)

neXtProt

NX_O15393

Antibodypedia

TMPRSS2 antibodies
 

PROTEIN VIEW

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TMPRSS2-001
 
TMPRSS2-003
 
TMPRSS2-008
 
TMPRSS2-009
 
TMPRSS2-010
 
TMPRSS2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMPRSS2-001 ENSP00000330330
ENST00000332149
O15393
Show all »
Show » Show » 492 53.9 No 1
TMPRSS2-003 ENSP00000397846
ENST00000424093
C9J5Y1
Show all »
Show » Show » 219 23.9 No 1
TMPRSS2-008 ENSP00000389006
ENST00000454499
C9JKZ3
Show all »
Show » Show » 489 53.6 No 1
TMPRSS2-009 ENSP00000391216
ENST00000458356
O15393
Show all »
Show » Show » 492 53.9 No 1
TMPRSS2-010 ENSP00000391784
ENST00000455813
C9JB05
Show all »
Show » 79 8.5 No 0
TMPRSS2-201 ENSP00000381588
ENST00000398585
O15393
Show all »
Show » Show » 529 57.7 No 1