SLC8A1 - Gene info - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Don't show this again.

SLC8A1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	SLC8A1 (HGNC Symbol)
Synonyms	NCX1
Description	Solute carrier family 8 (sodium/calcium exchanger), member 1 (HGNC Symbol)
Entrez gene summary	In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
Chromosome	2
Cytoband	p22.1
Chromosome location (bp)	40097270 - 40611053
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183023 (version 78.38)
Entrez gene	6546
UniProt	P32418 (UniProt - Evidence at protein level)
neXtProt	NX_P32418
Antibodypedia	SLC8A1 antibodies

PROTEIN VIEW

? »

SLC8A1-003		SLC8A1-004		SLC8A1-005		SLC8A1-006		SLC8A1-008		SLC8A1-009		SLC8A1-010		SLC8A1-012		SLC8A1-013		SLC8A1-201		SLC8A1-202

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC8A1-003	ENSP00000385678 ENST00000405901	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 E9PCL8 [Target identity:8%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	968	107.9	Yes	>9
SLC8A1-004	ENSP00000389330 ENST00000455476	E9PCL8 Show all » « Hide E9PCL8 [Target identity:100%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:96%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:83%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:80%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0035725 [sodium ion transmembrane transport]	87	9.8	Yes	0
SLC8A1-005	ENSP00000383886 ENST00000406785	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 E9PCL8 [Target identity:9%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	937	104.7	Yes	>9
SLC8A1-006	ENSP00000385188 ENST00000402441	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 E9PCL8 [Target identity:9%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	937	104.7	Yes	>9
SLC8A1-008	ENSP00000398575 ENST00000448531	E9PCL8 Show all » « Hide E9PCL8 [Target identity:100%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:96%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:83%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:80%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0035725 [sodium ion transmembrane transport]	87	9.8	Yes	0
SLC8A1-009	ENSP00000412560 ENST00000417271	E9PB98 Show all » « Hide E9PB98 [Target identity:100%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:95%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0035725 [sodium ion transmembrane transport]	73	8.2	Yes	0
SLC8A1-010	ENSP00000384763 ENST00000403092	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 Q4QQH3 [Target identity:39%; Query identity:100%] SLC8A1 protein {ECO:0000313\|EMBL:AAH98285.1} E9PCL8 [Target identity:8%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001892 [embryonic placenta development] GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0003007 [heart morphogenesis] GO:0005432 [calcium:sodium antiporter activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0009791 [post-embryonic development] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035050 [embryonic heart tube development] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0048747 [muscle fiber development] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	973	108.5	Yes	9
SLC8A1-012	ENSP00000385535 ENST00000405269	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 E9PCL8 [Target identity:9%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	937	104.7	Yes	>9
SLC8A1-013	ENSP00000384908 ENST00000408028	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 E9PCL8 [Target identity:9%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	965	107.8	Yes	>9
SLC8A1-201	ENSP00000332931 ENST00000332839	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 Q4QQH3 [Target identity:39%; Query identity:100%] SLC8A1 protein {ECO:0000313\|EMBL:AAH98285.1} E9PCL8 [Target identity:8%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	973	108.5	Yes	9
SLC8A1-202	ENSP00000385811 ENST00000406391	P32418 Show all » « Hide P32418 [Direct mapping] Sodium/calcium exchanger 1 E9PCL8 [Target identity:9%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000389330} Q6LAJ8 [Target identity:8%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73478.1} E9PB98 [Target identity:7%; Query identity:100%] Sodium/calcium exchanger 1 {ECO:0000313\|Ensembl:ENSP00000412560} Q6LAJ9 [Target identity:7%; Query identity:100%] Ncx1 protein {ECO:0000313\|EMBL:CAA73477.1}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002026 [regulation of the force of heart contraction] GO:0002027 [regulation of heart rate] GO:0005432 [calcium:sodium antiporter activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0006936 [muscle contraction] GO:0007154 [cell communication] GO:0007596 [blood coagulation] GO:0008092 [cytoskeletal protein binding] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling] GO:0014704 [intercalated disc] GO:0014829 [vascular smooth muscle contraction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0034614 [cellular response to reactive oxygen species] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0044557 [relaxation of smooth muscle] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0055013 [cardiac muscle cell development] GO:0055074 [calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060401 [cytosolic calcium ion transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0071313 [cellular response to caffeine] GO:0071436 [sodium ion export] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097369 [sodium ion import] GO:1901660 [calcium ion export]	937	104.7	Yes	>9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.